Fibroblast growth factor (FGF)-21 signals through both FGF receptor-1 and 2

被引：0
|
作者：
REN GuiPing
机构：
来源：
Science China(Life Sciences) | 2010年 / 08期
关键词：
FGF-21; FGF receptor-1; FGF receptor-2; glucose metabolism; Glut1;
D O I：
暂无
中图分类号：
Q25 [细胞生理学];
学科分类号：
071009 ; 090102 ;
摘要：
Fibroblast growth factor (FGF)-21 is a member of the FGF superfamily based on sequence homology. However, unlike most members of this family it does not show any mitogenic activity in all cell types tested. The objective of this study is to identify and characterize receptors for this molecule. Sequencing of the cDNA clones from 3T3-L1 adipocytes indicates that the only isoforms for FGFR-1 and 2 expressed in 3T3-L1 cells are 1IIIc and 2IIIc, respectively, suggesting that FGF-21 regulates glucose metabolism in 3T3-L1 adipocytes through FGFR-1IIIc and FGFR-2IIIc.
引用
收藏
页码：1000 / 1008
页数：9
相关论文
共 50 条
  • [31] Exon III splicing switch of fibroblast growth factor (FGF) receptor-2 and -3 can be induced by FGF-1 or FGF-2
    Scotet, E
    Houssaint, E
    ONCOGENE, 1998, 17 (01) : 67 - 76
  • [32] ALTERNATELY SPLICED NH2-TERMINAL IMMUNOGLOBULIN-LIKE LOOP-I IN THE ECTODOMAIN OF THE FIBROBLAST GROWTH-FACTOR (FGF) RECEPTOR-1 LOWERS AFFINITY FOR BOTH HEPARIN AND FGF-1
    WANG, F
    KAN, M
    YAN, GC
    XU, JM
    MCKEEHAN, WL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (17) : 10231 - 10235
  • [33] Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals
    Suzuki, Miwa
    Lee, Andrew Y.
    Vazquez-Medina, Jose Pablo
    Viscarra, Jose A.
    Crocker, Daniel E.
    Ortiz, Rudy M.
    GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2015, 216 : 86 - 89
  • [34] Fibroblast Growth Factor Receptor-2 Involved in FGF-21-mediated Glucose Metabolism
    Ren Gui-Ping
    Li Lu
    Sun Guo-Peng
    Hou Yu-Ting
    Wang Wen-Fei
    Li De-Shan
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2009, 36 (02) : 165 - 174
  • [35] Fibroblast growth factor (FGF)-21 regulates glucose uptake through GLUT1 translocation
    Liu, M. Y.
    Wang, W. F.
    Hou, Y. T.
    Yu, Y. X.
    Ren, G. P.
    Kern, T. S.
    Sun, G. P.
    Li, D. S.
    AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, 2012, 6 (10): : 2504 - 2511
  • [36] Selective inhibition of fibroblast growth factor (FGF)-stimulated mitogenesis by a FGF receptor-1-derived phosphopeptide
    Dunican, DJ
    Williams, EJ
    Howell, FV
    Doherty, P
    CELL GROWTH & DIFFERENTIATION, 2001, 12 (05): : 255 - 264
  • [37] Differential regulation of fibroblast growth factor (FGF) receptor-1 mRNA and protein by two molecular forms of basic FGF - Modulation of FGFR-1 mRNA stability
    Estival, A
    Monzat, V
    Miquel, K
    Gaubert, F
    Hollande, E
    Korc, M
    Vaysse, N
    Clemente, F
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (10) : 5663 - 5670
  • [38] Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination
    Messersmith, DJ
    Murtie, JC
    Le, TQ
    Frost, EE
    Armstrong, RC
    JOURNAL OF NEUROSCIENCE RESEARCH, 2000, 62 (02) : 241 - 256
  • [39] Stoichiometry of binding of fibroblast growth factor 7 (FGF-7) to FGF receptor 2IIIb
    Uematsu, F
    Jang, JH
    Kan, M
    McKeehan, WL
    MOLECULAR BIOLOGY OF THE CELL, 1998, 9 : 235A - 235A
  • [40] Fibroblast growth factor 2 (FGF2) and FGF receptor (FGFR) pipe expression in remyelinating lesions.
    Messersmith, DJ
    Murtie, JC
    Le, TQ
    Frost, EE
    Armstrong, RC
    JOURNAL OF NEUROCHEMISTRY, 2000, 74 : S58 - S58
12345