Gene Expression of Atrial Calcium - Handling Proteins in Patients with Rheumatic Heart Disease and Atrial Fibrillation

被引：0
|
作者：
伍伟锋
黄从新
刘唐威
朱树雄
机构：
[1] P R China
[2] Wuhan 430060
[3] Renmin Hospital of Wuhan University
[4] First Affiliated Hospital of Guangxi Medical University
[5] Nanning 530021
[6] Department of cardiology
来源：
SouthChinaJournalofCardiology | 2003年 / 01期
关键词：
Atrial fibrillation Calcium -handling protein Rheumatic heart disease;
D O I：
10.16268/j.cnki.44-1512/r.2003.01.004
中图分类号：
R541.2 [风湿性心脏病];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives To investigate the gene expression of calcium - handling proteins in patients with rheumatic heart disease (RHD) and atrial fibrillation (AF) . Methods A total of 50 patients with rheumatic mitral valve disease were included. According to cardiac rhythm and duration of episode of AF, patients were divided into four groups: sinus rhythm group, paroxysmal AF group, persistent AF for less than 6 months group and persistent AF for more than 6 months group. Atrial tissue was obtained from the right atrial appendage, the right atrial free wall and the left atrial appendage respectively during open heart surgery. Total RNA was isolated and reversly transcribed into cDNA. In a semi - quantitative polymerase chain reaction the cDNA of interest and of glyceralde-hyde3 - phosphate dehydrogenase (GAPDH) were amplified and separated by ethidium bromide - stained gel electrophoresis. Multiple liner regress was used for correlation between the mRNA amount and age, sex, right atrial diameter (RAd) and left a
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页码：11 / 16
页数：6
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