MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics

被引：6
|
作者：
Huimin Li [1 ]
Xiaoguang Zhao [1 ]
Hongli Shan [1 ]
Haihai Liang [1 ]
机构：
[1] Department of Pharmacology, College of Pharmacy, Harbin Medical University
来源：
ActaPharmaceuticaSinicaB | 2016年 / 6卷 / 06期
基金：
中国博士后科学基金;
关键词：
Idiopathic pulmonary fibrosis; MicroRNA; Pathogenesis; Early diagnosis; Therapeutic target; lncRNA;
D O I：
暂无
中图分类号：
R563 [肺疾病];
学科分类号：
摘要：
MicroRNAs(miRNAs) are a class of phylogenetically conserved, non-coding short RNAs,19–22 nt in length which suppress protein expression through base-pairing with the 30-untranslated region of target m RNAs. mi RNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis(IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some mi RNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of mi RNAs in the pathogenesis, diagnosis and treatment of IPF.
引用
收藏
页码：531 / 539
页数：9
相关论文
共 50 条
  • [41] A new direction in the pathogenesis of idiopathic pulmonary fibrosis?
    Gauldie J.
    Kolb M.
    Sime P.J.
    Respiratory Research, 3 (1)
  • [42] Expression analysis of serum microRNAs in idiopathic pulmonary fibrosis
    Li, Ping
    Li, Juan
    Chen, Tengfei
    Wang, Huaqi
    Chu, Heying
    Chang, Jingxia
    Zang, Wenqiao
    Wang, Yuanyuan
    Ma, Yunyun
    Du, Yuwen
    Zhao, Guoqiang
    Zhang, Guojun
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 33 (06) : 1554 - 1562
  • [43] Circulating MicroRNAs in Idiopathic Pulmonary Fibrosis: A Narrative Review
    Colin Waldo, Marisa Denisse
    Quintero-Millan, Xochipilzihuitl
    Negrete-Garcia, Maria Cristina
    Ruiz, Victor
    Sommer, Bettina
    Romero-Rodriguez, Damaris P.
    Montes-Martinez, Eduardo
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2024, 46 (12) : 13746 - 13766
  • [44] MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis
    Halkova, Tereza
    Cuperkova, Romana
    Minarik, Marek
    Benesova, Lucie
    GASTROENTEROLOGY RESEARCH AND PRACTICE, 2015, 2015
  • [45] Pathophysiological involvement of exosomes in idiopathic pulmonary fibrosis
    Stoeberl, Anna S.
    Krieger, Sigurd
    Kain, Renate
    Geleff, Silvana
    WIENER KLINISCHE WOCHENSCHRIFT, 2019, 131 (19-20) : 529 - 529
  • [46] Differential diagnosis of idiopathic pulmonary fibrosis
    Shmelev, E., I
    Ergeshov, A. E.
    Gergert, V. Ya
    TERAPEVTICHESKII ARKHIV, 2020, 92 (03) : 102 - 108
  • [47] Idiopathic Pulmonary Fibrosis: Diagnosis and Epidemiology
    Olson, Amy L.
    Swigris, Jeffrey J.
    CLINICS IN CHEST MEDICINE, 2012, 33 (01) : 41 - +
  • [48] Diagnosis and classification of idiopathic pulmonary fibrosis
    Kekevian, Alana
    Gershwin, M. Eric
    Chang, Christopher
    AUTOIMMUNITY REVIEWS, 2014, 13 (4-5) : 508 - 512
  • [49] The Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis
    Behr, Juergen
    DEUTSCHES ARZTEBLATT INTERNATIONAL, 2013, 110 (51-52): : 875 - +
  • [50] Considerations in the Diagnosis of Idiopathic Pulmonary Fibrosis
    Moodley, Yuben
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199 (05) : 665 - 666
12345