Astragalus polysaccharide enhances immunity and inhibits H9N2 avian influenza virus in vitro and in vivo

被引：46

作者：

Sanpha Kallon ^{[1
]}

Xiaorong Li ^{[1
]}

Jun Ji ^{[1
]}

Cuiying Chen ^{[1
]}

Qianyun Xi ^{[1
]}

Shuang Chang ^{[2
]}

Chunyi Xue ^{[3
]}

Jingyun Ma ^{[1
]}

Qingmei Xie ^{[1
]}

Youngliang Zhang ^{[1
]}

机构：

[1] College of Animal Science, South China Agricultural University

[2] US Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory

[3] State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-Sen University

来源：

JournalofAnimalScienceandBiotechnology | 2013年 / 4卷 / 04期

关键词：

Astragalus polysaccharide; H9N2 avian influenza virus; Immune effect;

D O I：

暂无

中图分类号：

S852.65 [家畜病毒学];

学科分类号：

摘要：

This study investigated the humoral immunization of Astragalus polysaccharide(APS) against H9N2 avian influenza virus(H9N2 AIV) infection in chickens. The effects of APS treatment on H9N2 infection was evaluated by an MTT [3(4, 5-dimethylthiazol-2-yl)-2, 3-diphenyl tetrazolium bromide] assay and analysis of MHC and cytokine mRNA expression. The effect on lymphocyte and serum antibody titers in vivo was also investigated. IL-4, IL-6, IL-10, LITAF, IL-12 and antibody titers to H9N2 AIV were enhanced in the first week after APS treatment. The results indicated that APS treatment reduces H9N2 AIV replication and promotes early humoral immune responses in young chickens.

引用

页码：325 / 335

页数：11

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