Study on Anti-inflammatory Effect of Total Flavonoids from FRUCTUS CANARII

[Objective] To observe anti-inflammatory effects of total flavonoids from FRUCTUS CANARII. [Method] Using the inhibition rate as index, three conventional models including dimethylbenzene-induced ear swelling, egg white-induced paw edema and acetic acid-induced celiac capillary permeability addition in mice were applied to evaluate the anti-inflammatory effect of total flavonoids from FRUCTUS CANARII. For each model, mice were divided into 5 groups, which were respectively injected with 80, 40, 20 mg/kg total flavonoids from FRUCTUS CANARII, 10 mg/kg dexamethasone and normal saline containing 5% Tween-80 (as blank control). [Result] Total flavonoids from FRUCTUS CANARII could inhibit the mouse ear swelling induced by dimethylbenzene, inhibit the mouse paw edema swelling induced by egg white and inhibit the increase of the mouse celiac capillary permeability induced by acetic acid. [Conclusion] Total flavonoids from FRUCTUS CANARII have certain anti-inflammatory effect.