Progress in studies of angio-statin and its anti-tumor effects

被引：0
|
作者：
YANG Hong
机构：
来源：
ChineseScienceBulletin | 2001年 / 06期
关键词：
angiostatin; angiogenesis; endothelial cell; anti-tumor;
D O I：
暂无
中图分类号：
R734.2 [肺肿瘤];
学科分类号：
摘要：
Angiostatin is a 38 ku circulating angiogenesis inhibitor purified from the serum and urine of mice bearing a murine Lewis lung carcinoma. It is regarded as an internal fragment of plasminogen containing the first 4 Kringle structures. In vitro, angiostatin specifically inhibits endothe-lial cell proliferation. In vivo, it inhibits angiogenesis and suppresses the growth of such primary tumors as Lewis lung carcinoma and hemangioendotheliolma in mice.
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页码：454 / 460
页数：7
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