Cardioprotection with adenosine in patients with ST-segment elevation myocardial infarction

To the editor:In a recently published issue,we have greatly enjoyed reading a well-designed study entitled "Three hours continuous injection of adenosine improved left ventricular function and infarct size in patients with ST-segment elevation myocardial infarction".Zhang et al investigated the effect of 3 hours infusion of adenosine started just after passing of a coronary guidewire during primary percutaneous intervention on left ventricular function and infart size in patients with ST-segment elevation myocardial infarction(STEMI).They reported favorable results with adenosine infusion and,discussed some possible mechanisms and large studies in their article,For better understanding of adenosine-mediated cardioprotection,some additional information appears to be needed.