The S100 family is a class of calcium regulated proteins with EF hand. They are widely distributed and are implicated in diverse intracellular and extracellular physiological processes. A study of the S100 family using computational biology methods such as multiple sequence alignment, structural alignment and the construction of an evolutionary tree will promote understanding of S100 protein structures and their function, and could provide suggestions for crystallization.
机构:
Univ York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, England
Kings Coll London, Sch Biomed & Hlth Sci, London WC2R 2LS, EnglandUniv York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, England