Copper-catalyzed α-selective C–H trifluoromethylation of acrylamides with TMSCF3

被引：1
|
作者：
Shang-Zheng Sun [1 ]
Hui Xu [2 ]
Hui-Xiong Dai [2 ]
机构：
[1] Department of Chemistry, Innovative Drug Research Center, Shanghai University
[2] Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences
来源：
Chinese Chemical Letters | 2019年 / 30卷 / 05期
基金：
中国国家自然科学基金;
关键词：
α-Selectivity; C–H trifluoromethylation; Copper; Acrylamides; Heterocycle;
D O I：
暂无
中图分类号：
O621.251 [];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed α-selective C–H trifluoromethylation of acrylamides with TMSCF3is described. A wide range of arenes and heteroarenes at the β-position of acrylamides are compatible with the reaction,affording the corresponding(E)-trifluoromethylated products in moderate to good yields. The reaction proceeded fast and can be completed within 30 min.
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页码：969 / 972
页数：4
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