非编码RNA在脑缺血再灌注损伤中的作用

被引:12
|
作者
张毅
冯康倪
陈鉴涛
梁孟亚
机构
[1] 中山大学附属第一医院心脏外科
基金
广东省自然科学基金;
关键词
脑缺血再灌注损伤; 长链非编码RNA; 微小RNA; 细胞凋亡; 自噬;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
摘要
<正>脑卒中(stroke)是导致成年人残疾和死亡的第二大病因,缺血性脑卒中约占所有脑卒中病例的87%[1],成为了现代社会健康和生活质量的主要威胁。缺血性脑卒中(ischemic stroke)由于脑血流量严重减少,脑组织缺乏血液和氧气供应,最终导致神经元细胞死亡和脑梗死[2]。目前临床上常用的治疗缺血性脑卒中的方法是及时恢复大脑的血液供应,然而部分病人恢复大脑血供后不仅不能减轻脑缺血引发的神经功能障碍,反而加重脑缺血症状,
引用
收藏
页码:347 / 355
页数:9
相关论文
共 56 条
  • [31] Upregulation of miR-216a exerts neuroprotective effects against ischemic injury through negatively regulating JAK2/STAT3-involved apoptosis and inflammatory pathways[J] . Tian Yu Shuang,Zhong Di,Liu Qing Qing,Zhao Xiu Li,Sun Hong Xue,Jin Jing,Wang Hai Ning,Li Guo Zhong.Journal of neurosurgery . 2018 (3)
  • [32] Long Noncoding RNAs: New Players in Ischaemia-Reperfusion Injury[J] . Si-yang Yu,Liang Tang,Sheng-hua Zhou.Heart, Lung and Circulation . 2018 (3)
  • [33] MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy[J] . Mirzaei Hamed,Momeni Fatemeh,Saadatpour Leila,Sahebkar Amirhossein,Goodarzi Mohammad,Masoudifar Aria,Kouhpayeh Shirin,Salehi Hossein,Mirzaei Hamid Reza,Jaafari Mahmoud Reza.Journal of cellular physiology . 2018 (2)
  • [34] Analysis of long non-coding RNA expression profiles following focal cerebral ischemia in mice[J] . Cuiying Liu,Jian Yang,Chencheng Zhang,Menglei Liu,Xiaokun Geng,Xunming Ji,Huishan Du,Heng Zhao.Neuroscience Letters . 2018
  • [35] Inhibition of MiRNA-125b Decreases Cerebral Ischemia/Reperfusion Injury by Targeting CK2α/NADPH Oxidase Signaling
    Liang, Yong
    Xu, Jing
    Wang, Yu
    Tang, Jia-Yu
    Yang, Song-Lin
    Xiang, Hong-Guang
    Wu, Shi-Xing
    Li, Xiao-Juan
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 45 (05) : 1818 - 1826
  • [36] Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling[J] . Hongxue Sun,Di Zhong,Jing Jin,Qingqing Liu,Haining Wang,Guozhong Li.Neuroscience Letters . 2018
  • [37] Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway
    Yan, Honglin
    Rao, Jie
    Yuan, Jingping
    Gao, Likun
    Huang, Wenxian
    Zhao, Lina
    Ren, Jiacai
    [J]. CELL DEATH & DISEASE, 2017, 8
  • [38] Downregulation of the Long Non-Coding RNA Meg3 Promotes Angiogenesis After Ischemic Brain Injury by Activating Notch Signaling
    Liu, Juan
    Li, Qing
    Zhang, Kun-shan
    Hu, Bin
    Niu, Xin
    Zhou, Shu-min
    Li, Si-guang
    Luo, Yu-ping
    Wang, Yang
    Deng, Zhi-feng
    [J]. MOLECULAR NEUROBIOLOGY, 2017, 54 (10) : 8179 - 8190
  • [39] The Role of Neurogenic Inflammation in Blood-Brain Barrier Disruption and Development of Cerebral Oedema Following Acute Central Nervous System (CNS) Injury
    Sorby-Adams, Annabel J.
    Marcoionni, Amanda M.
    Dempsey, Eden R.
    Woenig, Joshua A.
    Turner, Renee J.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (08)
  • [40] Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke
    Guo, Dong
    Ma, Ji
    Yan, Lei
    Li, Tengfei
    Li, Zhiguo
    Han, Xinwei
    Shui, Shaofeng
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 43 (01) : 182 - 194