Protective effect of Xuezhikang capsules in rats with acute myocardial ischemia reperfusion injury

Background Recent researches have found that stains can improve acute myocardial ischemia reperfusion injury which is achieved by inhibiting inflammatory reaction.Xuezhikang is extracted from red rice,a tailor-made Chinese crude drug.Main component of Xuezhikang that can inhibit blood-fat is statins.Methods Forty healthy SD rats (half male and half female,200 g or so) were randomly divided into four groups:A:normal control;B:sham operation;C:MIR group;D:Xuezhikang group.The acute myocardial ischemia reperfusion injury model was produced.Infarct sizes,MYO,CK-MB,cTnI,IL-10 and IL-18 were detected after reperfusion.Results Compared with C and D group,in A and B group,infarct size were increased significantly (P < 0.01),the level of serum MYO,CK-MB,cTnI were increased significantly (P < 0.01),the level of IL-10 were decreased significantly (P < 0.01) and IL-18,CRP were increased significantly (P < 0.01).Compared with C group,infarct size were decreased significantly (P < 0.05),the level of serum MYO,CK-MB and cTnI were increased significantly(P < 0.05),the level of IL-10 were increased significantly (P < 0.05) and IL-18 were decreased significantly (P < 0.05).The level of IL-10 and IL-18 were no difference between A and B group.Conclusion The application of Xuezhikang capsules on rats before the operation of myocardial ischemia reperfusion can lessen inflammatory reaction and reduce infarct sizes and protect acute myocardial ischemia reperfusion.