Calcium handling:a strategy to fight neurodegeneration in Alzheimer's disease

被引：0
|
作者：
Livia La Barbera [1 ,2 ]
Elena Spoleti [1 ]
Marcello D'Amelio [2 ,3 ]
机构：
[1] Department of Sciences and Technologies for Humans and Environment,Università Campus Bio-Medico di Roma
[2] Department of Experimental Neurosciences,IRCCS Santa Lucia Foundation  3. Department of Medicine and Surgery,Università Campus Bio-Medico di Roma
来源：
Neural Regeneration Research | 2023年 / 12期
关键词：
D O I：
暂无
中图分类号：
R749.16 [];
学科分类号：
100203 ;
摘要：
In the last few years,preclinical and clinical studies identified the ventral tegmental area(VTA) as one of the first brain regions to be affected in the prodromal phase of Alzheimer’s disease(AD).The VTA is a deep midbrain nucleus rich in dopaminergic neurons that innervates and releases dopamine(DA) in several cortical and subcortical brain regions.DA plays a crucial role in the modulation of both cognitive and noncognitive functions and failure of its release underlies both cognitive and neuropsychiatric symptoms in patients with AD.
引用
收藏
页码：2685 / 2686
页数：2
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