The Association between Myeloperoxidase-463G/A Gene Polymorphism and Coronary Artery Disease

To study the relationship between myeloperoxidase(MPO)-463G/A polymorphisms and susceptibility to coronary artery disease (CAD) in Han people of north Anhui province. Methods The case group consisted of 79 patients who had all angiographically proven CAD were retrospectively studied. Used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods to decide the genotype of all the patients. Results The frequency of AA homozygotic type in Han people of Anhui province was 1.4%. The risk of CAD for person carrying at least one A allele genotype (GA and AA) was 0.37 times of GG genotype. The severity of coronary artery stenosis in CAD patients carrying at least one A allele genotype was 0.197 times of GG genotype (P<0.05). Conclusions The frequency of AA homozygotic type and MPO-463G/A polymorphism in Han people of Anhui province influenced the risk of CAD. A allele had protective function in CAD.