Efficacy of nanofibrous conduits in repair of longsegment sciatic nerve defects

被引：0
|
作者：
Esmaeil Biazar [1 ]
Saeed Heidari Keshel [2 ,3 ]
Majid Pouya [4 ]
机构：
[1] Department of Biomaterial Engineering,Tonekabon Branch,Islamic Azad University,Tonekabon,Iran
[2] Student Research Committee,Proteomics Research Center,Faculty of Paramedical Sciences,Shahid Beheshti University of Medical Sciences,Tehran,Iran
[3] Department of Tissue Engineering,School of Advanced Technologies in Medicine,Tehran University of Medical Sciences,Tehran,Iran
[4] Faculty of Medical Sciences,Tonekabon Branch,Islamic Azad University,Tonekabon,Iran
来源：
Neural Regeneration Research | 2013年 / 8卷 / 27期
关键词：
neural regeneration; peripheral nerve injury; sciatic nerve; nerve conduit; poly(3-hydroxybutyrateco-3-hydroxyvalerate); behaviors; motor function; nociceptive function; grants-supported paper; neuroregeneration;
D O I：
暂无
中图分类号：
R651.3 [周围神经];
学科分类号：
1002 ; 100210 ;
摘要：
Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrateco-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects.However,the repair effects on rat behaviors remain poorly understood.In this study,we used nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous sciatic nerve to bridge 30-mm-long rat sciatic nerve gaps.Within 4 months after surgery,rat sciatic nerve functional recovery was evaluated per month by behavioral analyses,including toe out angle,toe spread analysis,walking track analysis,extensor postural thrust,swimming test,open-field analysis and nociceptive function.Results showed that rat sciatic nerve functional recovery was similar after nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous nerve grafting.These findings suggest that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit is suitable in use for repair of long-segment sciatic nerve defects.
引用
收藏
页码：2501 / 2509
页数：9
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