The blood-brain barrier models to study apolipoprotein E genotypes in Alzheimer's disease

被引：1

作者：

Irundika HK Dias ^{[1
]}

Rachelle Taiwo ^{[1
]}

Dan Ma ^{[1
]}

机构：

[1] Aston Medical School,College of Health and Life Sciences,Aston University

来源：

Neural Regeneration Research | 2022年 / 17卷 / 09期

关键词：

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by an agedependent progressive decline of memory,impairment of cognitive functions and changes in personality and behavior.Despite the improvement in understanding of the mechanisms underlying the disease ,AD remains an incurable complex disorder with multifaceted pathophysiology to date.Apolipoprotein E (Apo E) is the main cholesterol carrier in the brain that supports lipid transport between brain cells.The individuals carrying the APOE4 allele are known to be at increased risk of developing AD compared with those carrying the more common APOE3 allele.

引用

页码：1973 / 1974

页数：2

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