Therapeutic effect of bFGF on retina ischemia-reperfusion injury

被引：0
|
作者：
牛膺筠
赵岩松
高云霞
周占宇
王红云
袁春燕
机构：
[1] Department of Ophthalmology
[2] Affiliated Hospital of Medical College
[3] Qingdao University
[4] Qingdao 266003
[5] China
来源：
中华医学杂志(英文版) | 2004年 / 02期
关键词：
apoptosis; basic ftbroblast growth factor; calcium; caspase-3; ischemia-reperfusion injury;
D O I：
暂无
中图分类号：
R96 [药理学];
学科分类号：
100602 ; 100706 ;
摘要：
Background Basic fibroblast growth factor (bFGF) plays important roles in retina degeneration, light injury, mechanical injury, especially in retina ischemia-reperfusion injury (RIRI). This study was to investigate the therapeutical effect of bFGF on RIRI and its mechanisms.Methods Experimental RIRI was induced by increasing intraocular pressure (IOP) in the eyes of 48 rats. These rats were divided into normal control, ischemia-reperfusion and bFGF-treated groups. Histological and ultrastructural changes of in the retina of different groups were observed, and the number of retinal ganglion cells (RGCs) was quantitatively analyzed under microscopy. Apoptotic cells were detected using the TdT-dUTP terminal nick-end labeling (TUNEL) method. The expression of caspase-3 was determined by streptavidin peroxidase (SP) immunohistochemistry. Atomic absorption spectrum method was used to evaluate the intracellular calcium changes.Results At the early stage of retinal ischemia-reperfusion injury, retina edema in t
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页码：94 / 99
页数：6
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