Is the evolution in tumors Darwinian or non-Darwinian?

被引：0

|

作者：

Hurng-Yi Wang ^{[1
]}

Yuxin Chen ^{[2
]}

Ding Tong ^{[2
]}

Shaoping Ling ^{[2
,3
]}

Zheng Hu ^{[3
,4
]}

Yong Tao ^{[5
]}

Xuemei Lu ^{[3
]}

Chung-I Wu ^{[6
,3
,7
]}

机构：

[1] Graduate Institute of Clinical Medicine,Taiwan University

[2] State Key Laboratory of Biocontrol,School of Life Sciences,Sun Yat-Sen University

[3] Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences

[4] Stanford Cancer Institute,Stanford University School of Medicine

来源：

National Science Review | 2018年 / 5卷 / 01期

关键词：

Is the evolution in tumors Darwinian or non-Darwinian;

D O I：

暂无

中图分类号：

R730 [一般性问题];

学科分类号：

100214 ;

摘要：

Although Darwinian selection driving the genetic diversity within tumors has been widely assumed by the field of cancer biology,recent studies that employ the rigorous tests of population genetics have increasingly suggested otherwise.In these new studies[1-5],the non-Darwinian,or neutral,model of evolution can adequately explain the documented diversities in tumors without invoking natural selection.Therefore,the half-century-old debate of selectionism vs.neutralism[6-8]on the role of natural selection in populations is being

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页码：15 / 17

页数：3

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