The Releasing Effects of Captopril and Sodiun Nitroprusside on Endothelin-1 in Vascular Smooth Muscle Cell

被引：0
|
作者：
丛洪良
黄体钢
周丽娟
宋昱
马向虹
王伟
刘洪梅
机构：
[1] P R China
[2] The second hospital of Tianjin Medical University
[3] Department of Cardiology
[4] Tianjin Cardiology Institute 300211
来源：
South China Journal of Cardiology | 2001年 / 01期
关键词：
captorpil sodium nitroprusside endothelin - 1 nitric oxide VSMC;
D O I：
10.16268/j.cnki.44-1512/r.2001.01.011
中图分类号：
R965 [实验药理学];
学科分类号：
100602 ; 100706 ;
摘要：
Objective To investigate the influence of captoprial and SNP on the release of ET -1 in cultured VSMC of rats. Methods Measurement of endothelin - 1 levels by radioimmljnoassay in various concentrations of captopril and/or sodium nitroprusside in cultured vascular smooth muscle cell (VSMC) of rats. Results Both captopril and SNP could reduce the high ET - 1 levels of VSMC which were caused by Ang Ⅱ. There was a linear relationship between Ang Ⅱlevels and ET -1 production ( r = 0. 760, P <0. 001 ) . Conclusion Endothelin - 1 may accelerate the formation and development of atherosclerosis through inhibiting endogenous NO production by VSMC. ACEI or NO inhibition of ET -1 release could reduce atherosclerosis formation.
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页码：49 / 51
页数：3
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