Emerging functions of tRNA modifications in mRNA translation and diseases

被引：0

作者：

Lu Wang ^{[1
,2
]}

Shuibin Lin ^{[2
,3
]}

机构：

[1] Department of Medical Laboratory, School of Laboratory Medicine and Biotechnology, Southern Medical University

[2] Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University

[3] State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center

来源：

JournalofGeneticsandGenomics | 2023年 / 50卷 / 04期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

R394 [医学遗传学];

学科分类号：

0710 ; 071007 ;

摘要：

tRNAs are essential modulators that recognize mRNA codons and bridge amino acids for mRNA translation. The tRNAs are heavily modified, which are essential for forming a complex secondary structure that facilitates codon recognition and mRNA translation. In recent years, studies have identified the regulatory roles of tRNA modifications in mRNA translation networks. Misregulation of tRNA modifications is closely related to the progression of developmental diseases and cancers. In this review, we summarize the tRNA biogenesis process and then discuss the effects and mechanisms of tRNA modifications on tRNA processing and mRNA translation. Finally, we provide a comprehensive overview of the physiological and pathological functions of tRNA modifications, focusing on diseases including cancers.

引用

页码：223 / 232

页数：10

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