Preventive administration of cromakalim reduces aquaporin-4 expression and blood-brain barrier permeability in a rat model of cerebral ischemia/reperfusion injury

被引：0
|
作者：
Shilei Wang
机构：
来源：
NeuralRegenerationResearch | 2011年 / 6卷 / 13期
关键词：
cerebral ischemia/reperfusion; cromakalim; aquaporin-4; blood-brain barrier; brain edema;
D O I：
暂无
中图分类号：
R743 [脑血管疾病];
学科分类号：
摘要：
Cromakalim,an adenosine triphosphate-sensitive potassium channel opener,exhibits protective effects on cerebral ischemia/reperfusion injury.However,there is controversy as to whether this effect is associated with aquaporin-4 and blood-brain barrier permeability.Immunohistochemistry results show that preventive administration of cromakalim decreased aquaporin-4 and IgG protein expression in rats with ischemia/reperfusion injury;it also reduced blood-brain barrier permeability,and alleviated brain edema,ultimately providing neuroprotection.
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页码：1005 / 1009
页数：5
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