DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

被引：0

作者：

Mingquan Sha ^{[1
]}

Genxiang Mao ^{[2
]}

Guofu Wang ^{[2
]}

Yufeng Chen ^{[3
]}

Xiaojian Wu ^{[3
]}

Zhen Wang ^{[1
]}

机构：

[1] Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College

[2] Department of Colorectal Surgery,The Sixth Affiliated Hospital,Sun Yat-sen University

[3] Zhejiang Provincial Key Laboratory of Geriatrics & Geriatrics Institute of Zhejiang Province,Zhejiang Hospital

来源：

ActaPharmaceuticaSinicaB | 2015年 / 5卷 / 03期

基金：

中国国家自然科学基金;

关键词：

EZH2; Human colon cancer HCT116 cells; DZNep; Anti-cancer mechanisms;

D O I：

暂无

中图分类号：

R735.35 [];

学科分类号：

100214 ;

摘要：

EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation,metastasis and poor prognosis.Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer.3-Deazaneplanocin A(DZNep),as an EZH2 inhibitor,can suppress cancer cell growth.However,the anti-cancer role of DZNep in colon cancer cells has been rarely studied.In this study,we demonstrate that DZNep can inhibit the growth and survival of colon cancer HCT116 cells by inducing cellular senescence and apoptosis.The study provides a novel view of anti-cancer mechanisms of DZNep in human colon cancer cells.

引用

页码：188 / 193

页数：6

共 50 条

[21] Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway
Yang, Min
Li, Wen-Yun
Xie, Jing
Wang, Zi-Lin
Wen, Yan-Long
Zhao, Cun-Chao
Tao, Liang
Li, Ling-Fei
Tian, Yang
Sheng, Jun
FRONTIERS IN PHARMACOLOGY, 2021, 12
[22] MicroRNA miR-425 inhibits proliferation and migration of colorectal cancer HCT116 cells
Zhou, Huifang
Liu, Wen
Chen, Haiyun
Ni, Jiajia
Zhang, Zhi
Xu, Aimin
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, 2021, 71 (09) : 2167 - 2172
[23] Quercetin enhances hypoxia-mediated apoptosis in HCT116 colon cancer
Kim, Hak-Su
Lee, Mingyoung
Ha, Joohun
FASEB JOURNAL, 2008, 22
[24] Curcumin and 3′ 4′ didemethylnobiletin in combination synergistically inhibit cell proliferation and potentiate apoptosis in HCT116 colon cancer cells
DiMarco-Crook, Christina
Zheng, Jinkai
Song, Minyue
Xiao, Hang
FASEB JOURNAL, 2014, 28 (01):
[25] Characterization of HCT116 human colon cancer cells in an orthotopic modeld
Rajput, Ashwani
Martin, Ivan Dominguez San
Rose, Rebecca
Beko, Alexander
LeVea, Charles
Sharratt, Elizabeth
Mazurchuk, Richard
Hoffman, Robert M.
Brattain, Michael G.
Wang, Jing
JOURNAL OF SURGICAL RESEARCH, 2008, 147 (02) : 276 - 281
[26] Regenerating gene 1B silencing inhibits colon cancer cell HCT116 proliferation and invasion
Liu, Zhirong
Zhang, Yuehong
Xie, Jun
Li, Caiping
Wang, Xiaoxia
Shen, Jinyan
Zhang, Yiqiang
Wang, Shiyu
Cheng, Niuliang
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2015, 30 (02): : E217 - E225
[27] Entrainment of superoxide rhythm by menadione in HCT116 colon cancer cells
Uma Kizhuveetil
Meghana V. Palukuri
Priyanshu Sharma
Devarajan Karunagaran
Raghunathan Rengaswamy
G. K. Suraishkumar
Scientific Reports, 9
[28] Apoptotic effect of Naphthoquinone derivatives on HCT116 colon cancer cells
Young-Sam Im
Yongseog Chung
Dae Yeon Won
Soo Han Kwon
Hye-Ryun Kim
Dong Geun Lee
Seung-Ryul Kim
Kyung Do Park
Hak-Kyo Lee
Joong-Kook Choi
Genes & Genomics, 2010, 32 : 592 - 598
[29] Apoptotic effect of Naphthoquinone derivatives on HCT116 colon cancer cells
Im, Young-Sam
Chung, Yongseog
Won, Dae Yeon
Kwon, Soo Han
Kim, Hye-Ryun
Lee, Dong Geun
Kim, Seung-Ryul
Park, Kyung Do
Lee, Hak-Kyo
Choi, Joong-Kook
GENES & GENOMICS, 2010, 32 (06) : 592 - 598
[30] Procaine Induces Epigenetic Changes in HCT116 Colon Cancer Cells
Sabit, Hussein
Samy, Mariam B.
Said, Osama A. M.
El-Zawahri, Mokhtar M.
GENETICS RESEARCH INTERNATIONAL, 2016, 2016

← 1 2 3 4 5 →