Curcumin protects against interleukin-6-induced rapid Ca～(2+) influx in rat hippocampal neurons

被引：0
|
作者：
Qinying Deng1
机构：
来源：
Neural Regeneration Research | 2011年 / 6卷 / 24期
关键词：
curcumin; interleukin-6; hippocampus; neurons; Ca2+ channel;
D O I：
暂无
中图分类号：
R285.5 [中药实验药理];
学科分类号：
1008 ;
摘要：
The current study sought to investigate the potential protective action of curcumin against interleukin-6-induced injury in rat hippocampal neurons.The results revealed that interleukin-6 induced typical cellular injury,such as the swelling of cell bodies and increased Ca2+ concentration.After administration of curcumin,interleukin-6-induced neurons recovered to a normal state,and the fluorescence intensity of Ca2+ gradually returned to normal.These findings suggest that curcumin exerts a protective effect on hippocampal neurons of rats.In addition,our results suggest that the protective effect of curcumin involves prevention of the rapid Ca2+ influx induced by interleukin-6,which maintains Ca2+ homeostasis.
引用
收藏
页码：1850 / 1854
页数：5
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