Perioperative Changes of Plasma TNF-α, IL-6 in Patients Undergoing Upper Abdominal Operation

被引：0
|
作者：
Qian Yanning(钱燕宁) Liu Cunming(刘存明) Zhang Guolou(张国楼) Bao Yintang(包荫堂)\+1 Chen Ziqing(陈子庆)\+2 Department of Anesthesiology
机构：
来源：
Journal of Nanjing Medical University | 2000年 / 01期
关键词：
cytokine; TNF; α; IL; 6; stress; anesthesia; surgery;
D O I：
暂无
中图分类号：
R446.1 [生物化学检验、临床检验];
学科分类号：
摘要：
Objective\ To investigate the perioperative chaneges of plasma levels of necrosis factor α(TNF α) and interleukin 6 (IL 6). Methods\ Thirty patients undergoing upper abdominal operations were randomly divied into epidural blockade (EB) group and intravenous procaine balanced anesthesia (IPBA) group. The plasma levels of TNF α and IL 6 were monitored perioperatively. Results\ There were no significant changes in TNF α in both groups during or after operation. But plasma IL 6 levels on the first postoperative day were significantly higher than that before induction of anesthesia in both groups [EB:(0 39±0 07) vs (0 28±0 07) ng/ml, P<0.05; IPBA:(0 42±0 07) vs (0.27±0.08) ng/ml, P<0.05]. Conclusion\ The results suggest that IL 6 is a cytokine more active than TNF α after upper abdominal operation. Surgical stress might be a more important stimulator for IL 6 release.
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页码：24 / 26
页数：3
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