Neural stem cells promote neuroplasticity:a promising therapeutic strategy for the treatment of Alzheimer's disease

被引:0
|
作者
Jun Chang [1 ,2 ]
Yujiao Li [1 ,2 ]
Xiaoqian Shan [1 ,2 ]
Xi Chen [1 ,2 ]
Xuhe Yan [1 ,2 ]
Jianwei Liu [3 ]
Lan Zhao [1 ,2 ]
机构
[1] First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
[2] National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion
[3] Tianjin University of Traditional Chinese Medicine
基金
中国国家自然科学基金;
关键词
D O I
暂无
中图分类号
R749.16 [];
学科分类号
100203 ;
摘要
Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and neurogenesis, exists throughout the normal lifespan but declines with age and is significantly impaired in individuals with Alzheimer’s disease. Hence, promoting neuroplasticity may represent an effective strategy with which Alzheimer’s disease can be alleviated. Due to their significant ability to selfrenew, differentiate, and migrate, neural stem cells play an essential role in reversing synaptic and neuronal damage, reducing the pathology of Alzheimer’s disease, including amyloid-β, tau protein, and neuroinflammation, and secreting neurotrophic factors and growth factors that are related to plasticity. These events can promote synaptic plasticity and neurogenesis to repair the microenvironment of the mammalian brain. Consequently, neural stem cells are considered to represent a potential regenerative therapy with which to improve Alzheimer’s disease and other neurodegenerative diseases. In this review, we discuss how neural stem cells regulate neuroplasticity and optimize their effects to enhance their potential for treating Alzheimer’s disease in the clinic.
引用
收藏
页码:619 / 628
页数:10
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