Effects of electroacupuncture versus nimodipine on long-term potentiation and synaptophysin expression in a rat model of vascular dementia

被引：0
|
作者：
Dengming Wei
机构：
来源：
NeuralRegenerationResearch | 2011年 / 6卷 / 30期
关键词：
vascular dementia; electroacupuncture; learning and memory ability; long-term potentiation; synaptophysin; neural regeneration;
D O I：
暂无
中图分类号：
R245 [针灸学、针灸疗法];
学科分类号：
100512 ;
摘要：
The present study stimulated Baihui (DU 20) and Dazhui (DU 14) acupoints in a rat model of vascular dementia with electroacupuncture to investigate changes in long-term potentiation and synaptophysin expression in the hippocampus.The results revealed that synaptophysin expression in brain tissues was increased after electroacupuncture.After high-frequency stimulation,the population spike latency was shortened and the excitatory postsynaptic potential slope and population spike amplitude were increased.In addition,cognitive function was enhanced,similar to the effects of intragastric perfusion of nimodipine.The results indicated that electroacupuncture at Baihui and Dazhui acupoints can improve learning and memory functions of a rat model of vascular dementia by promoting synaptophysin expression,enhancing hippocampal synaptic plasticity and accelerating synaptic transmission.
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收藏
页码：2357 / 2361
页数：5
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