Hypoglycemic Activity of Lotus Root Polysaccharides and Its Effect on Antioxidant Activity in Vivo

[Objective] To investigate the hypoglycemic activity of lotus root polysaccharides on diabetic mice and its effect on antioxidant activity in vivo.[Method] Diabetic mice model were induced by intraperitoneal injection with alloxan.Normal control group,diabetic control group,glyburide control group and 3 groups of lotus root polysaccharide including low-dose,medium-dose and high-dose group were employed in this study.[Result] Lotus root polysaccharide showed efficacies on relieving emaciation,lowering blood glucose and promoting the glucose tolerance of diabetic mice.In addition,it was also endowed with effects on increasing SOD activity of liver,kidney and pancreas in diabetic mice,and on reducing the content of MDA.[Conclusion] This study could provide a theoretical basis for the development of new natural hypoglycemic drugs.