Contribution of neutrophils in the pathogenesis of rheumatoid arthritis

被引：0
|
作者：
Lingshu Zhang [1 ,2 ]
Yi Yuan [3 ]
Qiang Xu [1 ,2 ]
Zhengyu Jiang [3 ]
Cong-Qiu Chu [1 ,2 ]
机构：
[1] Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University
[2] Department of Rheumatology and Immunology, the First Hospital of Jilin University
[3] Rheumatology Section, VA Portland Healthcare System
来源：
The Journal of Biomedical Research | 2020年 / 34卷 / 02期
关键词：
neutrophils; rheumatoid arthritis; NET formation;
D O I：
暂无
中图分类号：
R593.22 [类风湿性关节炎];
学科分类号：
1002 ; 100201 ;
摘要：
Neutrophils are major innate immune effector cells for host defense and have been a topic of active research for their participation in the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis(RA)due to recently discovered neutrophil extracellular trap(NET) formation. NET formation and other mechanisms leading to the release of neutrophil nuclear and cytoplasmic contents are implicated as a source of citrullinated antigens in RA. Further investigations are required to delineate what factors diverge neutrophils from host defense to autoimmune response in RA.
引用
收藏
页码：86 / 93
页数：8
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