The influencing factors of renal response in newly diagnosed multiple myeloma patients with renal impairment

Objective To investigate the causative factors of renal function in newly diagnosed multiple myeloma(MM) patients with renal inadequacy.Methods 181MM patients with renal impairment from August 2007 to October 2021 at Peking Union Medical College Hospital were recruited,whose baseline chronic kidney disease(CKD) stage was 3-5.Statistical analysis was performed based on laboratory tests,treatment regimens,hematological responses,and survival among various renal function efficacy groups.A logistic regression model was employed in multivariate analysis.Results A total of 181 patients were recruited,and 277 patients with CKD stages 1-2 were chosen as controls.The majority were chosen according to the BCD and VRD regimens.The progression-free survival(PFS)(14.0 months vs24.8 months,P <0.001) and overall survival(OS)(49.2 months vs 79.7 months,P <0.001) of patients with renal impairment was considerably shorter.