Correlation of serum lipids, lipoproteins, lipid peroxide products and metals with coronary heart disease

Serum lipids, lipoproteins, malondialdelyde (MDA) and metal levels were determined in 86 patients with coronary heart disease (CHD) proved angiographically and 33 controls subjects. Serum concentrations of TC, LDL-C, AI, MDA and Cu were significantly elevated and serum HDL-C, Zn and Mg contents were decreased markedly in patients. Correlation analyses indicated that the severity of coronary arterial lesions was related positively to serum TC, LDL-C, AI, MDA and Cu levels, and inversely to HDL-C levels; both the serum Cu and MDA contents were related positively to TC and LDL-C levels. These data suggest that serum Cu and MDA might have effects on the extent of CA lesions during the progress of atherosclerosis in patients with CHD.