Design, Synthesis and Biological Activity of N-Sulfonyl Aromatic Amide Derivatives

被引：1

作者：

刘汶芮 ^{[1
]}

华学文 ^{[1
]}

周沙 ^{[2
]}

袁凤英 ^{[1
]}

王桂清 ^{[1
]}

刘艺 ^{[1
]}

邢晓冉 ^{[3
]}

机构：

[1] College of Agriculture, Liaocheng University

[2] Collaborative Innovation Center of Zhejiang Province for Green Pesticide, School of Forestry and Bio-technology, Zhejiang A&F University

[3] Liaocheng Center for Disease Control and Prevention

来源：

Chinese Journal of Structural Chemistry | 2021年 / 40卷 / 05期

基金：

中国国家自然科学基金;

关键词：

heterocyclic amide; synthesis; crystal structure; fungicidal activity; nematicidal activity;

D O I：

10.14102/j.cnki.0254-5861.2011-2991

中图分类号：

TQ450.1 [基础理论];

学科分类号：

090403 ;

摘要：

Fifteen novel N-sulfonyl aromatic amide derivatives were designed and synthesized, and the structures were characterized by ~1H-andC-NMR, EA and HRMS. The crystal structures of compounds I-8 and I-9 were obtained from X-ray diffraction: I-8 is of triclinic system, Mr = 372.35, space group P2/n with a = 7.9151(10), b = 8.5637(11), c = 12.2022(15) ?, β = 86.865(2)o, V = 807.09(18) ?~3, Z = 2, F(000) = 384, D= 1.532 g/cm~3, the final R = 0.0408 and wR = 0.1068 for 2836 unique reflections with 2435 observed ones(I > 2σ(I)). I-9 belongs to triclinic system, M= 407.39, space group P2/n, with a = 8.4911(8), b = 8.6053(9), c = 14.5808(15) ?, β = 77.1190(10)o, V = 995.44(17) ?~3, Z = 2, F(000) = 416, D= 1.359 g/cm~3, the final R = 0.0567 and wR = 0.1779 for 3475 unique reflections with 2392 observed ones(I > 2σ(I)). The preliminary bioassay results indicated that the target compounds showed weak nematicidal activity, while compound I-5 displayed good fungicidal activity against Colletotrichum capsici with the inhibition rate of 61.7%.

引用

页码：666 / 674

页数：9

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