Protein Dynamical Structure Revealed by Temperature-jump Time-resolved Infrared Spectroscopy

Protein could carry out its biological function only when it is folded into the right conformation,and the conformation might be changing during the activation process,therefore protein dynamical structure provides a key clue to understand its function.Although many protein static structures have been resolved by X-ray crystallography,2D NM and cryoelectron microscope at atomic level,the static structure could be different from the dynamical structure,especially under physiological condition.In their continuous effort to study the protein dynamical structure with temperature-jump time-resolved infrared spectroscopy(Biophys.J.2007,93,2756–2766;Biophys.J.2009,97,2756–2766),a team lead by Prof.WENG Yuxiang from the Institute of Physics(IOP),Chinese Academy of Sciences recently collaborated with Prof.CHANG Zengyi’s