Efficacy of topical dorzolamide 2% in diabetic cystoid macular edema

AIM: To study the effect of topical dorzolamide 2% on macular thickness reduction in diabetic cystoid macular edema(CME).METHODS: This was a prospective, non-randomized, open study including eyes with diabetic macular edema(DME). All eyes received topical dorzolamide 2% three times daily for one month. Changes in best-corrected visual acuity(BCVA), and central macular thickness(CMT) by optical coherence tomography) were evaluated at 1 wk, 1, and 3 mo post-treatment.RESULTS: Ninety-three eyes(84 patients) were included. Mean±SD(log MAR) BCVA improved significantly from 1.08±0.26 pretreatment to 0.66±0.24 at 1 mo and 0.87±0.26 at 3 mo post-treatment(P<0.001 both). The mean±SD CMT was significantly reduced from 535.27±97.4 μm at baseline to 357.43±125.8 μm at 1 mo and 376.23±114.5 μm at 3 mo post-treatment(P<0.001 both). No significant ocular or systemic side effects were recorded.CONCLUSION: Topical dorzolamide 2% results in significant improvement of mean BCVA and reduction of mean CMT at 3 mo post-treatment. It can be used as an effective, affordable, and safe therapy for treatment of nonrefractory diabetic CME.