Development of novel agents based on nitric oxide for the control of colon cancer

被引:0
|
作者
Vassiliki KOZONI
Theophilos ROSENBERG
Basil RIGAS
机构
[1] Division of Cancer Prevention,Stony Brook University Stony Brook,NY 11794-5200,USA
[2] First Department of Surgery Laikon Hospital,Athens University,11527 Athens,Greece
关键词
nitric oxide-donating NSAIDs; nitric oxide aspirin; colon cancer; chemoprevention nitric oxide;
D O I
暂无
中图分类号
R735.3 [肠肿瘤];
学科分类号
100214 ;
摘要
Nitric oxide-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs) repre-sent a novel class of compounds that hold promise as agents for the control ofcolon cancer.They are derivatives of conventional NSAIDs that have been modi-fied by adding to them,via a spacer molecule,a nitric oxide releasing moiety.Theexpectation is that the combined effects of NO and the NSAID moiety will exceedthose of each structural component alone.Extensive work has demonstrated theirpotency and efficacy in preclinical models of colon cancer.The mechanism ofaction of NO-NSAIDs involves the modulation of several critical cellular signalingpathways,whereas the induction of a state of oxidative stress,at least by NO-aspirin,appears to be a major proximal event.Clinical trials are needed to assessthe role of NO-NSAIDs in the control of colon cancer.
引用
收藏
页码:1429 / 1433
页数:5
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