Selenocysteine tRNAs as Central Components of Selenoprotein Biosynthesis in Eukaryotes

被引：0
|
作者：
SANG ICK PARK
JIN Mo PARK
HAROLD S. CHITTUM
EUN SUNG YANG
BRADLEY A. CARLSON
BYEONG JAE LEE AND DOLPH L. HATFIELD(Laboratory of Experimental Chrcinogenesis
Laboratory o
机构：
来源：
Biomedical and Environmental Sciences | 1997年 / Z1期
关键词：
tRNA; gene; Selenocysteine tRNAs as Central Components of Selenoprotein Biosynthesis in Eukaryotes;
D O I：
暂无
中图分类号：
R394 [医学遗传学];
学科分类号：
0710 ; 071007 ;
摘要：
Selenocysteine (Sec) tRNAs serve as carrier molecules for the biosynthesis of Sec from serine and to donate Sec to protein in response to specific UGA codons. In this study, we describe the current status of Sec tRNAs in higher animals and further we exarnine: (i) the Sec tRNA population in Drosophila; (ii) transcription of the Sec tRNA in vivo (in Xenopus oocytes) and in vitro (in Xenopus oocyte extracts); (iii) the effect of selenium on the Sec tRNA population in various rat tissues following replenishment of extremely selenium deficient rats with this element; and (iv) the biosynthesis of the modified bases on Sec tRNA in Xenopus oocytes
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页码：116 / 124
页数：9
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