The potential risks of C-C chemokine receptor 5-edited babies in bone development

被引：0

作者：

Yong Xie ^{[1
]}

Shaohua Zhan ^{[2
]}

Wei Ge ^{[2
]}

Peifu Tang ^{[1
]}

机构：

[1] Department of Orthopedics,Chinese PLA General Hospital

[2] State Key Laboratory of Medical Molecular Biology and Department of Immunology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences

来源：

Bone Research | 2019年 / 01期

基金：

中国国家自然科学基金;

关键词：

CCR; The potential risks of C-C chemokine receptor 5-edited babies in bone development;

D O I：

暂无

中图分类号：

R714.8 [];

学科分类号：

摘要：

INTRODUCTION Hutter et al.1first reported that a bone marrow transplant using stem cells derived from a donor with homozygous CCR5 delta32gene mutation remained HIV-positive but virus-free (below the limits of detection) after halting antiretroviral therapy.Since this observation in 2009,mutation of the CCR5 gene has become an important target in the prevention and treatment of HIV infection.

引用

页码：118 / 121

页数：4

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