Synthesis and anticancer properties of tungstosilicic polyoxometalate containing 5-fluorouracil and neodymium

被引：0

作者：

刘霞 ^{[1
]}

王帅帅 ^{[2
]}

冯长根 ^{[2
]}

机构：

[1] College of Science, China Agricultural University

[2] State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology

来源：

Journal of Rare Earths | 2010年 / 28卷 / 06期

关键词：

polyoxometalate; 5-fluorouracil; neodymium; cytotoxicity; HepG-2; rare earths;

D O I：

暂无

中图分类号：

O614.335 [];

学科分类号：

070301 ; 081704 ;

摘要：

A novel tungstosilicic polyoxometalate containing 5-fluorouracil and Nd, K26(C4H4FN2O2)8Nd(SiW11O39)4·5H2O (FNSW) was synthesized and its structure was characterized by using elemental analysis, FT-IR spectra, X-ray powder diffraction, UV-vis spectra and TG. The results indicated that the compound FNSW had Keggin structure of heteropolyanion and ring structure of 5-fluorouracil, and it had a good thermal stability. With 5-fluorouracil for the positive control group, the cytotoxicity tests in human renal embryonic cell HEK293 and the antitumor activity tests in hepatocellular carcinoma cell HepG-2 were carried out by the methyl thiazolyl tetrazolium method. The toxicity of the compound FNSW was lower than that of 5-fluorouracil, and compared with 5-fluorouracil the compound FNSW could inhibit HepG-2 cell in vitro with significant difference. The rare earth element Nd increased the biological activity of polyoxometalate significantly.

引用

页码：965 / 968

页数：4

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