Determination of Sparfloxacin in Human Urine by Reversed-Phase High Performance Liquid Chromatography With Nitrous Acid and Hydroiodic Pre-Column Derivatization

被引：0
|
作者：
Li Ming DU1*
机构：
来源：
Chinese Chemical Letters | 2001年 / 11期
关键词：
Sparfloxacin; HPLC; pre-column derivatization; human urine;
D O I：
暂无
中图分类号：
O657.7 [色谱分析];
学科分类号：
070302 ; 081704 ;
摘要：
Sparfloxacin can be oxidized by nitrous acid, then react with hydroiodic acid to form a fluorescent derivative. Based on this, a reversed-phase high performance liquid chromatographic pre-column derivatization new method is described for the determination of sparfloxacin in human urine. The linear range is 0.05 mg/L to 4.0 mg/L, the recoveries are 91.5%～95.7% and the RSD is 1.2%~4.2%. The results showed that this method is suitable for the determination of sparfloxacin in human urine.
引用
收藏
页码：1007 / 1010
页数：4
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