IGF-1 inhibited the apoptosis of gastric smooth muscle cells induced by high glucose through AMPK-Akt-mTOR pathway

被引：0
|
作者：
张香子 [1 ]
机构：
[1] Dept Clin Med,Yanbian Univ Med Sch
来源：
ChinaMedicalAbstracts(InternalMedicine) | 2023年 / 40卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R587.2 [糖尿病性昏迷及其他并发症];
学科分类号：
1002 ; 100201 ;
摘要：
Objective To investigate the effect of insulin-like growth factor 1(IGF-1) on rat gastric smooth muscle cell apoptosis and key proteins of AMPK-Akt-mTOR pathway and to explore the related mechanisms.Methods Rat gastric smooth muscle cells cultured in vitro were divided into two groups:high glucose group(HG group) and high glucose and IGF-1 group(HG+IGF-1 group).The glucose concentration was 35 mmol/L in both groups.IGF-1 concentration was 100 mmol/L in HG+ IGF-1group.The flow cytometry was used to observe cell apoptosis.The protein expression of Bcl-2,BAX,
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页码：90 / 90
页数：1
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