Development of CAR T cell therapy targeting glypican-3 in liver cancer

被引：0
|
作者：
Dan Li [1 ]
Nan Li [1 ]
Yifan Zhang [1 ]
Haiying Fu [1 ]
Madeline B.Torres [1 ]
Tim F.Greten [1 ]
Mitchell Ho [1 ]
机构：
[1] Center for Cancer Research, National Cancer Institute
来源：
Cancer Biology & Medicine | 2018年 / 15(S1)卷 / S1期
关键词：
HCC; GPC; Development of CAR T cell therapy targeting glypican-3 in liver cancer;
D O I：
暂无
中图分类号：
R735.7 [肝肿瘤];
学科分类号：
100214 ;
摘要：
Objective:Glypican-3(GPC3)is a promising therapeutic target in hepatocellular carcinoma(HCC).We have generated the HN3 and h YP7 antibodies that recognize the N-lobe and C-lobe of GPC3,respectively.Here,we engineered human T cells that express GPC3-specific chimeric antigen receptors(CARs)and evaluated their potential for the treatment of HCC.
引用
收藏
页码：17 / 17
页数：1
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