Development of CAR T cell therapy targeting glypican-3 in liver cancer

被引：0

作者：

Dan Li ^{[1
]}

Nan Li ^{[1
]}

Yifan Zhang ^{[1
]}

Haiying Fu ^{[1
]}

Madeline B.Torres ^{[1
]}

Tim F.Greten ^{[1
]}

Mitchell Ho ^{[1
]}

机构：

[1] Center for Cancer Research, National Cancer Institute

来源：

Cancer Biology & Medicine | 2018年 / 15(S1)卷 / S1期

关键词：

HCC; GPC; Development of CAR T cell therapy targeting glypican-3 in liver cancer;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

Objective:Glypican-3(GPC3)is a promising therapeutic target in hepatocellular carcinoma(HCC).We have generated the HN3 and h YP7 antibodies that recognize the N-lobe and C-lobe of GPC3,respectively.Here,we engineered human T cells that express GPC3-specific chimeric antigen receptors(CARs)and evaluated their potential for the treatment of HCC.

引用

页码：17 / 17

页数：1

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