Genetic diversity in Ebola virus:Phylogenetic and in silico structural studies of Ebola viral proteins

被引：0

作者：

Alba Grifoni ^{[1
]}

Alessandra Lo Presti ^{[2
]}

Marta Giovanetti ^{[2
,3
]}

Carla Montesano ^{[3
]}

Massimo Amicosante ^{[1
,4
]}

Vittorio Colizzi ^{[3
]}

Alessia Lai ^{[5
]}

Gianguglielmo Zehender ^{[5
]}

Eleonora Cella ^{[2
,6
]}

Silvia Angeletti ^{[7
]}

Massimo Ciccozzi ^{[2
,8
]}

机构：

[1] ProxAgen Ltd.Sofia.Bulgaria 2. Department of Infectious Parasitic and Immunomediated Diseases,National Institute of Health

[2] Department of Biology,University of Rome 'Tor Vergata'

[3] Department of Biomedicine and Prevention,University of Rome Tor Vergata

[4] Laboratory of Infectious Diseases and Tropical Medicine,University of Milan

[5] Department of Public Health and Infectious Diseases.Sapienza University of Rome.Rome

[6] Clinical Pathology and Microbiology Laboratory,University Hospital Campus Bio-Medico of Rome

[7] University Campus Bio-Medico

来源：

Asian Pacific Journal of Tropical Medicine | 2016年 / 04期

关键词：

Ebola virus; Proteins; Evolutionary analysis;

D O I：

暂无

中图分类号：

R373 [人体病毒学（致病病毒）];

学科分类号：

100103 ; 100705 ;

摘要：

Objective:To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola Virus.Methods:Sequences retrieved from public databases,the selective pressure analysis and the homology modelling based on the all protein(nucleoprotein.VP35,VP40.soluble glycoprotein,small soluble glycoprotein.VP30,VP24 and polymerase) were used.Results:Structural proteins VP24.VP30.VP35 and VP40 showed relative conserved sequences making them suitable target candidates for antiviral treatment.On the contrary,nucleoprotein.polymerase and soluble glycoprotein have high mutation frequency.Conclusions:Data from this study point out important aspects of Ebola virus sequence variability that for epitope and vaccine design should be considered for appropriate targeting of conserved protein regions.

引用

页码：329 / 335

页数：7

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