EFFECTS OF CEREBRAL CORTICAL CONCIS ON CELL PROLIFERATION OF THE SUBVENTRICULAR ZONE IN ADULT RATS

被引：0
|
作者：
张越林
邱曙东
张篷勃
师蔚
机构：
[1] Department of Huma Anatomy Histology and Embryology Medical School of Xi’an Jiaotong University Xi’an 710061 China
[2] Department of Huma Anatomy Histology and Embryology Medical School of Xi’an Jiaotong University Xi’an 710061 China
来源：
Journal of Pharmaceutical Analysis | 2006年 / 02期
基金：
中国国家自然科学基金;
关键词：
neural stem cells; neural progenitor cells; neurogenesis; brain injury; rat;
D O I：
暂无
中图分类号：
R651.1 [颅脑];
学科分类号：
1002 ; 100210 ;
摘要：
Objective To investigate the proliferative response and time course of endogenous neural stem/progenitor cells after cerebral cortical concis in the adult rats. Methods Eighty adult male Sprague-Dawley rats were used in this study. Cumulative BrdU labeling was employed to detect the proliferating cells. At 1d, 3d, 7d, 14d, and 21d after cerebral cortical concis, the rats were killed for BrdU immunohistochemical staining and cell counting in the injured ipsilateral SVZ. Results Little BrdU immunoreactivity cells was present in SVZ of the control rats from day 7 to day 21 after sham operation. The number of BrdU immunoreactivity cells in the injured ipsilateral SVZ increased at day 1 and peaked at day 7 after cerebral cortical concis. Conclusion After cerebral cortical concis of the adult rats, neural stem/progenitor cells in the injured ipsilateral SVZ markedly proliferated with a peak at day 7. This finding may be important for manipulating SVZ cells to promote the recovery from cerebral cortical concis.
引用
收藏
页码：191 / 194
页数：4
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