Exploration on Significance of Platelet CD62p, CD63 Determination in Type 2 Diabetes Mellitus Patients with Blood Stasis Syndrome

Objective: To study the relationship between blood stasis syndrome (BSS) and platelet activation and its influencing factors in type 2 diabetic mellitus (DM).Methods: Platelet CD 62p , CD 63 expressions were determined in 30 type 2 DM patients with BSS, 27 type 2 DM patients without BSS and 20 normal controls by flow cytometry. Results: CD 62p , CD 63 levels were significantly higher in type 2 DM group with BSS than those in the type 2 DM group without BSS and in the normal controls. CD 62p was positively correlated with CD 63 , while positive correlation existed between HbA 1c, LDLC and CD 62p in DM patients with BSS. Conclusions: The increased level of platelet activation was the primary molecular basis of BSS in type 2 DM. It was important to perform the syndrome differentiation of BSS and treatment of activating blood flow to remove BSS in type 2 DM.