Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons

被引：0

作者：

Sarah Buchholz ^{[1
,2
]}

Hans Zempel ^{[1
,2
]}

机构：

[1] Institute of Human Genetics,Faculty of Medicine and University Hospital Cologne,University of Cologne

[2] Center for Molecular Medicine Cologne(CMMC),Faculty of Medicine and University Hospital Cologne,University of Cologne

来源：

Neural Regeneration Research | 2024年 / 08期

关键词：

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

Introduction:TAU isoforms as disease mediators:The microtubule-associated protein TAU is predominantly present in the axons of neurons under physiological conditions.In Alzheimer’s disease(AD) and related tauopathies,TAU also mislocalizes( "TAU missorting") to the soma and the dendrites,where it eventually forms aggregates,

引用

页码：1655 / 1657

页数：3

共 28 条

[21] Immunization with a synthetic fragment 155–164 of neurotrophin receptor p75 prevents memory loss and decreases beta-amyloid level in mice with experimentally induced Alzheimer’s disease
O. M. Volpina
N. I. Medvinskaya
A. V. Kamynina
Y. V. Zaporozhskaya
I. J. Aleksandrova
D. O. Koroev
A. N. Samokhin
T. D. Volkova
A. S. Arseniev
N. V. Bobkova
Russian Journal of Bioorganic Chemistry, 2014, 40 : 417 - 422
[22] Ameliorating Activity of Ishige okamurae on the Amyloid Beta-Induced Cognitive Deficits and Neurotoxicity through Regulating ERK, p38 MAPK, and JNK Signaling in Alzheimer's Disease-Like Mice Model
Kwon, Oh Yun
Lee, Seung Ho
MOLECULAR NUTRITION & FOOD RESEARCH, 2020, 64 (12)
[23] Immunization with a synthetic fragment 155-164 of neurotrophin receptor p75 prevents memory loss and decreases beta-amyloid level in mice with experimentally induced Alzheimer's disease
Volpina, O. M.
Medvinskaya, N. I.
Kamynina, A. V.
Zaporozhskaya, Y. V.
Aleksandrova, I. J.
Koroev, D. O.
Samokhin, A. N.
Volkova, T. D.
Arseniev, A. S.
Bobkova, N. V.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2014, 40 (04) : 417 - 422
[24] Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease
Abdul, Hafiz Mohmmad
Calabrese, Vittorio
Calvani, Menotti
Butterfield, D. Allan
JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 84 (02) : 398 - 408
[25] Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease (vol 27, pg 1332, 2018)
Manczak, Maria
HUMAN MOLECULAR GENETICS, 2023, 32 (20) : 3027 - 3027
[26] Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer's disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway, endoplasmic reticulum stress, and cellular senescence
Awad, Heba H.
Desouky, Mahmoud A.
Zidan, Alaa
Bassem, Mariam
Qasem, Amaal
Farouk, Mona
AlDeab, Haidy
Fouad, Miral
Hany, Cherry
Basem, Nada
Nader, Rita
Alkalleny, Ashrakat
Reda, Verina
George, Mina Y.
INFLAMMOPHARMACOLOGY, 2023, 31 (05) : 2653 - 2673
[27] Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer’s disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway, endoplasmic reticulum stress, and cellular senescence
Heba H. Awad
Mahmoud A. Desouky
Alaa Zidan
Mariam Bassem
Amaal Qasem
Mona Farouk
Haidy AlDeab
Miral Fouad
Cherry Hany
Nada Basem
Rita Nader
Ashrakat Alkalleny
Verina Reda
Mina Y. George
Inflammopharmacology, 2023, 31 : 2653 - 2673
[28] RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum-induced Alzheimer's disease-like rat model
Han, Fei
Xu, Hui
Shen, Jun-Xian
Pan, Chuan
Yu, Zong-Hao
Chen, Jing-Jing
Zhu, Xiu-Ling
Cai, Ya-Fei
Lu, Ya-Ping
ACTA NEUROBIOLOGIAE EXPERIMENTALIS, 2020, 80 (03) : 225 - 244

← 1 2 3 →