Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons

被引：0

作者：

Sarah Buchholz ^{[1
,2
]}

Hans Zempel ^{[1
,2
]}

机构：

[1] Institute of Human Genetics,Faculty of Medicine and University Hospital Cologne,University of Cologne

[2] Center for Molecular Medicine Cologne(CMMC),Faculty of Medicine and University Hospital Cologne,University of Cologne

来源：

Neural Regeneration Research | 2024年 / 08期

关键词：

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

Introduction:TAU isoforms as disease mediators:The microtubule-associated protein TAU is predominantly present in the axons of neurons under physiological conditions.In Alzheimer’s disease(AD) and related tauopathies,TAU also mislocalizes( "TAU missorting") to the soma and the dendrites,where it eventually forms aggregates,

引用

页码：1655 / 1657

页数：3

共 28 条

[1] Suppression of mature TAU isoforms prevents Alzheimer's disease-like amyloid-beta oligomer-induced spine loss in rodent neurons
Buchholz, Sarah
Zempel, Hans
NEURAL REGENERATION RESEARCH, 2024, 19 (08) : 1655 - 1657
[2] Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer's Disease
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[3] Plasma amyloid-beta oligomer and phosphorylated tau:diagnostic tools for progressive Alzheimer's disease
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[4] Plasma amyloid-beta oligomer and phosphorylated tau: diagnostic tools for progressive Alzheimer's disease
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[7] Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a foxed double transgenic model of Alzheimer's disease
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Castello, Nicholas A.
Green, Kim N.
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[8] Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer's disease-like transgenic (pPDGF-APPSW,Ind) mice
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Qiao, Shuhong
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[9] Brazilian green propolis prevent Alzheimer's disease-like cognitive impairment induced by amyloid beta in mice
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BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2023, 23 (01)
[10] Brazilian green propolis prevent Alzheimer’s disease-like cognitive impairment induced by amyloid beta in mice
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BMC Complementary Medicine and Therapies, 23

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