Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?

被引：0

作者：

Jing Ge ^{[1
,2
]}

Jun Wang ^{[2
]}

Dan Xue ^{[3
]}

Zhengsheng Zhu ^{[4
]}

Zhenyu Chen ^{[3
]}

Xiaoqiu Li ^{[2
]}

Dongfeng Su ^{[5
]}

Juan Du ^{[1
]}

机构：

[1] Department of Gynecology and Obstetrics,Shengjing Hospital of China Medical University

[2] The General Hospital of Shenyang Military Region

[3] Department of Gynecology and Obstetrics,People's Liberation Army No.202 Hosiptal

[4] Dantu District Sanitary Supervision Institute

[5] Department of Neurology,the 463 Hospital of Chinese PLA

来源：

NeuralRegenerationResearch | 2013年 / 8卷 / 20期

关键词：

neural regeneration; preeclampsia; eclampsia; excitatory neurotransmitter; neurotoxicity; hyperlip-idemia; hypertension; pregnancy; lipoprotein-associated phospholipase A2; metabotropic glutamate receptor 1; grants-supported paper; neuroregeneration;

D O I：

暂无

中图分类号：

R714.245 [];

学科分类号：

摘要：

Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as hyper-tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein ex-pressions were upregulated in the rat hippocampus. These findings indicate that increased expres-sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced pree-clampsia in pregnant rats.

引用

页码：1872 / 1880

页数：9

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