Rapamycin affect the apoptosis of splenic CD4+ CD25+ regulatory T cells of mouse severe aplastic anemia model

被引：1
|
作者：
林赠华 [1 ]
机构：
[1] Dept Hematol, Affili Hosp, Nantong Univ
来源：
China Medical Abstracts (Internal Medicine) | 2018年 / 35卷 / 02期
关键词：
Rapamycin affect the apoptosis of splenic CD4; regulatory T cells of mouse severe aplastic anemia model;
D O I：
暂无
中图分类号：
R-332 [医用实验动物学]; R965 [实验药理学];
学科分类号：
1001 ; 100602 ; 100706 ;
摘要：
Objective To explore the effects and possible mechanism of rapamycin(RAPA)on apoptosis of CD4+CD25+Tregs from the mouse severe aplastic anemia(SAA)model.Methods The BALB/c female SAA model mice were induced by interferon-gamma in combination with busulphan.The SAA model mice were intraperitoneal injection with RAPA at daily dose of 0.5 mg/kg
引用
收藏
页码：117 / 118
页数：2
相关论文
共 50 条
  • [31] Daily subcutaneous injections of peptide induce CD4+ CD25+ T regulatory cells
    Dahlberg, P. E.
    Schartner, J. M.
    Timmel, A.
    Seroogy, C. M.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 149 (02): : 226 - 234
  • [32] Specificity of CD4+ CD25+ regulatory T cells in a novel TCR transgenic model of alloimmunity.
    Sandner, SE
    Sanchez-Fueyo, A
    Domenig, C
    Zheng, XX
    Turka, LA
    Strom, TB
    Sayegh, MH
    AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 : 271 - 271
  • [33] CD4+ CD25+ T regulatory cells and proinflammatory cytokines in Egyptians with rheumatoid arthritis
    Wesam S. Ibrahim
    Hanan M. El Saadany
    Manal A. Abd El khalek
    Mahamoud F. Seliem
    Egyptian Rheumatology and Rehabilitation, 2013, 40 (2) : 121 - 127
  • [34] CD4+ CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions
    Suvas, S
    Azkur, AK
    Kim, BS
    Kumaraguru, U
    Rouse, BT
    JOURNAL OF IMMUNOLOGY, 2004, 172 (07): : 4123 - 4132
  • [35] Depletion of CD4+ CD25+ regulatory T cells inhibits local tumour growth in a mouse model of B cell lymphoma
    Heier, I.
    Hofgaard, P. O.
    Brandtzaeg, P.
    Jahnsen, F. L.
    Karlsson, M.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2008, 152 (02): : 381 - 387
  • [36] The role of self-peptides in the development of CD4+ CD25+ regulatory T cells
    Picca, CC
    Caton, AJ
    CURRENT OPINION IN IMMUNOLOGY, 2005, 17 (02) : 131 - 136
  • [37] The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis
    Wisnoski, Nicholas
    Chung, Chun-Shiang
    Chen, Yaping
    Huang, Xin
    Ayala, Alfred
    SHOCK, 2007, 27 (03): : 251 - 257
  • [38] Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state
    Fisson, S
    Darrasse-Jèze, G
    Litvinova, E
    Septier, F
    Klatzmann, D
    Liblau, R
    Salomon, BL
    JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (05): : 737 - 746
  • [39] Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells
    Nishikawa, H
    Kato, T
    Tawara, I
    Saito, K
    Ikeda, H
    Kuribayashi, K
    Allen, PM
    Schreiber, RD
    Sakaguchi, S
    Old, LJ
    Shiku, H
    JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (05): : 681 - 686
  • [40] CD4+ CD25+ FoxP3+ regulatory T cells in autoimmune diseases
    Valencia, Xavier
    Lipsky, Peter E.
    NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2007, 3 (11): : 619 - 626
12345