Clinical signs and genetic sequencing of benign recurrent intrahepatic cholestasis

Benign recurrent intrahepatic cholestasis（BRIC）is a rare autosomal recessive liver disease characterized by intermittent attacks of cholestasis that was first reported by Summerskill and Walshe in 1959.A few reports on patients with BRIC in China have been described in recent years,however,it is still a challenge to give the patients a correct diagnosis.Therefore,we collected five cases in the Beijing Friendship Hospital and the China-Japan Friendship Hospital in the past two years to summarize their clinical features,and explore the mutation region of the ATP8B1gene from Chinese patients with BRIC.