Comparative Evaluation of the Functional Potential of Mesenchymal Stem Cells from the Bichat’s Fat Pad, Bone Marrow, and Adipose Tissue for Bone Tissue Regeneration

被引：0
|
作者：
N. A. Bondarenko [1 ]
M. A. Surovtseva [1 ]
I. I. Kim [1 ]
S. V. Ostapets [2 ]
O. S. Kosareva [2 ]
M. N. Drovosekov [2 ]
O. V. Poveshchenko [1 ]
机构：
[1] Siberian Branch of the Russian Academy of Sciences,Scientific Institution of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics
[2] Novosibirsk State Medical University,undefined
[3] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2025年 / 178卷 / 5期
关键词：
mesenchymal stem cells; Bichat’s fat pad; proliferation; osteogenic differentiation; erythropoietin;
D O I：
10.1007/s10517-025-06378-y
中图分类号：
学科分类号：
摘要：
The functional potential of mesenchymal stem cells (MSC) isolated from Bichat’s fat pad for osteoinduction in dentistry was compared with that of MSC from the adipose tissue and bone marrow. Functional activity of MSC was evaluated by the rate of their proliferation, migration, and differentiation into osteoblasts under the influence of erythropoietin. MSC from the Bichat’s fat pad have higher proliferative activity than MSC from the adipose tissue or bone marrow under the influence of platelet-enriched plasma. Moreover, they are characterized by low migration activity, differentiate into osteoblasts, and intensively produce alkaline phosphatase under the influence of erythropoietin. The revealed functional potential of MSC from the Bichat’s fat pad makes them promising for cell therapy, including osteoinduction in dentistry.
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页码：581 / 585
页数：4
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