Urocortin2 measurement for heart failure assessment

被引：0

作者：

Kohei Inukai ^{[1
]}

Kazuya Miyashita ^{[2
]}

Kazuhiko Kotani ^{[3
]}

Ryota Morimoto ^{[1
]}

Toru Kondo ^{[1
]}

Hiroaki Hiraiwa ^{[1
]}

Shingo Kazama ^{[1
]}

Tatsuya Yoshida ^{[1
]}

Satoya Yoshida ^{[1
]}

Tomoki Hattori ^{[1
]}

Kumiko Fukamachi ^{[2
]}

Naoya Fukui ^{[2
]}

Katsuhiro Kato ^{[1
]}

Yoshimitsu Yura ^{[1
]}

Koji Ohashi ^{[4
]}

Noriyuki Ouchi ^{[4
]}

Toyoaki Murohara ^{[1
]}

Takahiro Okumura ^{[1
]}

Mikito Takefuji ^{[1
]}

机构：

[1] Nagoya University Graduate School of Medicine,Department of Cardiology

[2] Immuno-Biological Laboratories,Division of Community and Family Medicine

[3] Jichi Medical University,Department of Molecular Medicine and Cardiology

[4] Nagoya University School of Medicine,undefined

来源：

Scientific Reports | / 15卷 / 1期

关键词：

Heart failure; UCN2; ELISA assay; CRHR2; GPCR; Peptide;

D O I：

10.1038/s41598-025-99509-4

中图分类号：

学科分类号：

摘要：

Despite the efficacy of many therapies for heart failure, it remains a leading cause of morbidity and mortality worldwide, with many patients progressing to advanced stages of the condition. Since the standard treatment for heart failure includes small-molecule drugs targeting G protein-coupled receptors (GPCRs), GPCRs are still considered novel targets for the diagnosis and treatment of cardiovascular diseases. Corticotropin-releasing hormone receptor 2, a highly expressed GPCR in cardiomyocytes, and its ligand, urocortin2 (UCN2), have been reportedly associated with cardiovascular diseases; however, their clinical significance remains unclear. In this study, a UCN2 measurement assay was developed to measure blood UCN2 levels in patients with heart failure. The assay showed that blood UCN2 values indicated a negative relationship with cardiac ejection fraction in 52 patients with heart failure. Blood UCN2 levels were not correlated with brain natriuretic peptide, a standard marker of heart failure, and were higher in patients with cardiomyopathy than in those with heart failure, suggesting that measuring blood UCN2 levels may be a novel test for assessing the pathophysiology of heart failure.

引用

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